Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

5-2015

Journal or Book Title

ACS Biomaterials Science & Engineering

Volume

1

Issue

6

First Page

425

Last Page

430

DOI

10.1021/acsbiomaterials.5b00042

Abstract

The wide usage and subsequent leakage of nonsteroidal anti-inflammatory drugs (NSAIDs) into the environment present an urgent need to create materials for selective binding of NSAID drugs, which are highly similar to one another in structure and functionality. Surface–core double-cross-linking of cationic micelles containing Naproxen or Indomethacin as the template yielded molecularly imprinted nanoparticles (MINPs) for these drugs. The nanoparticle receptors resembled water-soluble proteins in their hydrophilic exterior and hydrophobic core with guest-tailored binding pockets. Their binding selectivity for their templates over other NSAID analogues rivaled that of antibodies prepared through much lengthier procedures.

Comments

Reprinted (adapted) with permission from ACS Biomaterials Science & Engineering 1 (2015): 425, doi:10.1021/acsbiomaterials.5b00042. Copyright 2015 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

Included in

Chemistry Commons

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