Tuning the Sensitivity of a Foldamer-Based Mercury Sensor by Its Folding Energy

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2006-07-01
Authors
Zhao, Yan
Zhong, Zhenqi
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Zhao, Yan
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Abstract

A fluorescent sensor for Hg2+ was obtained by incorporation of two methionine units into a cholate hexamer and by attaching a Dansyl group at the chain end. Folding could be made highly favorable or unfavorable in different solvents. Because folding was required to bring the sulfur groups together to chelate the mercury ion, binding affinity of the foldamer and, thus, its sensitivity as a sensor, could be tuned over broad ranges (at least 5 orders of magnitude) by solvent changes.

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Reprinted (adapted) with permission from Journal of the American Chemical Society 128 (2006): 9988, doi:10.1021/ja062001i. Copyright 2006 American Chemical Society.

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Sun Jan 01 00:00:00 UTC 2006
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