Regiocontrol by Remote Substituents. A Direct Total Synthesis of Racemic Hongconin
Reprinted (adapted) with permission from Journal of Organic Chemistry 59 (1994): 2219, doi:10.1021/jo00087a044. Copyright 1994 American Chemical Society.
The total synthesis of hongconin (1) has been completed. Key steps include the metalation of a benzylic alcohol, the formation of a six-membered ring ether via a mercury-mediated cyclization, and the regioselective installation of the naphthalene ring by way of a Diels-Alder reaction.