Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

4-22-2010

Journal or Book Title

Analytical Chemistry

Volume

82

Issue

10

First Page

4097

Last Page

4101

DOI

10.1021/ac100179u

Abstract

The feasibility of exploiting fluorescence spectra of the eye for diagnosis of transmissible spongiform encephalopathies (TSEs) was examined. Retinas from scrapie-positive sheep were compared with scrapie-negative sheep using fluorescence spectroscopy, and distinct differences in the fluorescence intensity and spectroscopic signatures were observed. The characteristic fluorescent signatures are thought to be the result of an accumulation of lipofuscin in the retina. It appears that the eye, in particular the retina, is a useful tissue for noninvasive examination of some neurological pathologies such as scrapie. The development of procedures based on examinations of the eye that permit the detection of neurological disorders in animals holds great promise.

Comments

Reprinted (adapted) with permission from Analytical Chemistry 82 (2010): 4097, doi: 10.1021/ac100179u. Copyright 2010 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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