Title
Fluorescence Spectroscopy of the Retina for Diagnosis of Transmissible Spongiform Encephalopathies
Campus Units
Chemistry
Document Type
Article
Publication Version
Published Version
Publication Date
4-22-2010
Journal or Book Title
Analytical Chemistry
Volume
82
Issue
10
First Page
4097
Last Page
4101
DOI
10.1021/ac100179u
Abstract
The feasibility of exploiting fluorescence spectra of the eye for diagnosis of transmissible spongiform encephalopathies (TSEs) was examined. Retinas from scrapie-positive sheep were compared with scrapie-negative sheep using fluorescence spectroscopy, and distinct differences in the fluorescence intensity and spectroscopic signatures were observed. The characteristic fluorescent signatures are thought to be the result of an accumulation of lipofuscin in the retina. It appears that the eye, in particular the retina, is a useful tissue for noninvasive examination of some neurological pathologies such as scrapie. The development of procedures based on examinations of the eye that permit the detection of neurological disorders in animals holds great promise.
Copyright Owner
American Chemical Society
Copyright Date
2010
Language
en
File Format
application/pdf
Recommended Citation
Adhikary, Ramkrishna; Mukherjee, Prasun; Krishnamoorthy, Govindarajan; Kunkle, Robert A.; Casey, Thomas A.; Rasmussen, Mark A.; and Petrich, Jacob W., "Fluorescence Spectroscopy of the Retina for Diagnosis of Transmissible Spongiform Encephalopathies" (2010). Chemistry Publications. 569.
https://lib.dr.iastate.edu/chem_pubs/569
Included in
Chemistry Commons, Veterinary Pathology and Pathobiology Commons, Veterinary Physiology Commons
Comments
Reprinted (adapted) with permission from Analytical Chemistry 82 (2010): 4097, doi: 10.1021/ac100179u. Copyright 2010 American Chemical Society.