Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

2-1994

Journal or Book Title

The Journal of Organic Chemistry

Volume

59

Issue

4

First Page

922

Last Page

923

DOI

10.1021/jo00083a038

Abstract

Compounds containing the adamantane subunit have long been of interest to chemists due to the rigid structure and well-defined substitution chemistry of adamantane.l The discovery of the potent antiviral activity of amantadine (1-aminoadamantane) and rimantadine (a-methyl-l-adamantylmethylamine) has stimulated interest in the synthesis of adamantane-containing compounds.2 The significant neuroprotective properties of the NMDA antagonist memantine3 (l-amino-3,5-dimethyladamantane) have also prompted interest in adamantane synthesis

Comments

Reprinted (adapted) with permission from The Journal of Organic Chemistry, 59(4); 922-923. Doi: 10.1021/jo00083a038. Copyright 1994 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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