Campus Units

Chemistry

Document Type

Article

Publication Version

Published Version

Publication Date

12-1995

Journal or Book Title

Biochemistry

Volume

34

Issue

48

First Page

15845

Last Page

15848

DOI

10.1021/bi00048a030

Abstract

Hypocrellin A displays photoinduced antiviral activity, in particular against the human immunodeficiency virus (HIV), as does its counterpart, hypericin. Although hypocrellin A, like hypericin, executes an excited-state intramolecular proton transfer, it differs from hypericin in two important ways. Unlike hypericin, hypocrellin A absolutely requires oxygen for its antiviral activity. Also, whereas we have previously demonstrated that hypericin functions as a light-induced proton source, we do not observe that hypocrellin A acidifies its surrounding medium in the presence of light. These results are discussed in the context of the ground- and excited-state photophysics of hypericin and its mechanisms of photoinduced virucidal activity.

Comments

Reprinted (adapted) with permission from Biochemistry 34 (1995): 15845, doi:10.1021/bi00048a030. Copyright 1995 American Chemical Society.

Copyright Owner

American Chemical Society

Language

en

File Format

application/pdf

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