Synthesis and testing of analogs of Helminthosporium maydis race T toxin
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
Several analogues of Helminthosponum maydis race T toxin were prepared. The synthesis of the hydroxy diketones was accomplished by aldol condensations of 2-decanone with ketal aldehydes followed by deketalization. The dihydroxy ketone analogues were prepared by use of dihydroisoxazole intermediates. The analogues were tested and found to be less active than the parent toxin. The analogues still exhibited host specificity.
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Reprinted (adapted) with permission from Journal of Agricultural and Food Chemistry, 32(6); 1265-1268. Doi: 10.1021/jf00126a014. Copyright 1984 American Chemical Society.