Campus Units
Chemistry
Document Type
Article
Publication Version
Published Version
Publication Date
9-1985
Journal or Book Title
The Journal of Organic Chemistry
Volume
50
Issue
18
First Page
3252
Last Page
3255
DOI
10.1021/jo00218a002
Abstract
An extremely direct route to the 6-deoxyanthracycline skeleton is described. The initial route to quinone 10 failed due to an unexpected complication in the Ago demethylation step. However, starting from 2-bromo- 1,4-dimethoxynaphthalene, furan 17 could be prepared in two steps. Furan 17 was then converted into anthraquinone 19 in five steps. The eight-step route proceeds in 9% overall yield.
Copyright Owner
American Chemical Society
Copyright Date
1985
Language
en
File Format
application/pdf
Recommended Citation
Kraus, George A. and Hagen, Michael D., "Synthesis of novel 6-deoxyanthracyclines" (1985). Chemistry Publications. 715.
https://lib.dr.iastate.edu/chem_pubs/715
Included in
Environmental Chemistry Commons, Inorganic Chemistry Commons, Organic Chemistry Commons, Other Chemistry Commons, Polymer Chemistry Commons
Comments
Reprinted (adapted) with permission from The Journal of Organic Chemistry, 50(18); 3252-3255. Doi: 10.1021/jo00218a002. Copyright 1985 American Chemical Society.