Facile synthesis of N-acyl-2-pyrrolines
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
In conjunction with our studies of the amidoalkylation reaction,' multigram quantities of N-acyl-2-pyrrolines (1) were needed. Interestingly, only a few methods for the synthesis of this class of compounds had been reported. Stille and co-workers prepared 1 by a novel transition metal mediated isomerization of N-acyl-3-pyrrolines2 and also cyclized (acy1amino)butyraldehydes to produce le3 Although these methods are excellent for qmall-scale preparation, large-scale reactions would entail considerable expense.
Comments
Reprinted (adapted) with permission from The Journal of Organic Chemistry,46(23); 4791-4792. Doi: 10.1021/jo00336a036. Copyright 1981 American Chemical Society.