Journal or Book Title
Journal of The American Chemical Society
Several macrocyclic lactones of the trichothecene class of compounds exhibit significant anticancer activity.' A common structural subunit in each of these lactones is the sesquiterpene verrucarol(1). Anguidin (2), a more highly oxygenated analogue, also shows inhibitory activity against several cancers., Calonectrin (3), considered to be the biogenetic precursor to verru~arol,~ has recently been isolated.
American Chemical Society
Kraus, George A.; Roth, Bruce; Frazier, Kevin; and Shimagaki, Masayuki, "Stereoselective synthesis of calonectrin" (1982). Chemistry Publications. 796.