Campus Units

Ames Laboratory, Chemistry

Document Type

Article

Publication Version

Accepted Manuscript

Publication Date

2011

Journal or Book Title

Small

Volume

7

Issue

11

First Page

1526

Last Page

1532

DOI

10.1002/smll.201002077

Abstract

The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The exo­cytosis of highly adsorbent magnetic MSNs proves to be useful as a means for harvesting biomolecules from living cells.

Comments

This is the peer reviewed version of the following article: Slowing, I. I., Vivero-Escoto, J. L., Zhao, Y., Kandel, K., Peeraphatdit, C., Trewyn, B. G. and Lin, V. S.-Y. (2011), Exocytosis of Mesoporous Silica Nanoparticles from Mammalian Cells: From Asymmetric Cell-to-Cell Transfer to Protein Harvesting. Small, 7: 1526–1532. doi:10.1002/smll.201002077, which has been published in final form at 10.1002/smll.201002077. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Copyright Owner

Wiley-VCH

Language

en

File Format

application/pdf

Published Version

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