Title
Degree Type
Creative Component
Semester of Graduation
Spring 2019
Department
Biomedical Sciences
First Major Professor
Jon Mochel
Degree(s)
Master of Science (MS)
Major(s)
Biomedical Sciences
Abstract
With chemotherapy and radiation being the most common forms of cancer treatment, some cancer cells are able to develop resistance and persist in the body. Because of this resistance, there is a need for a new cancer therapy that can attack these persistent cells. CAR T cell therapy utilizes the patient’s own immune system to attack and potentially eliminate these cancer cells. These cells have successfully been used against B cell malignancies, however, not much success has been seen when used against solid tumors. Solid tumors pose many challenges and threats these T cells must overcome in order to produce any anti-tumor effect. Challenges researchers run into include finding a suitable antigen to target, successfully trafficking to and infiltrating the tumor, and overcoming the microenvironment of the tumor. Researchers are continuously trying to figure out ways to overcome these challenges and increase the success of CAR T cell therapy
Copyright Owner
Megan Bonnett
Copyright Year
2019
File Format
application/pdf
Recommended Citation
Bonnett, Megan, "CAR T Cell Therapy" (2019). Creative Components. 141.
https://lib.dr.iastate.edu/creativecomponents/141
