Semester of Graduation
First Major Professor
Master of Science (MS)
Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. The motor symptoms include bradykinesia and resting tremor while the non-motor symptoms associate with sleeping disorders and olfactory dysfunctions. Besides that, patients may experience hyposmia prior being diagnosed with PD. Thus, the present project’s objective is to confirm a new dopaminergic pathway, which contributes to hyposmia link in pre-exposed PD patients. In order to validate the nigro-olfactory pathway, the MitoPark model was set up in the combination of several techniques including cryosectioning, mounting, and fluorescent microscopy. After collecting data, there were significant fluorescent of FG tracers emitted at Striatum. In order to validate the hypothesis, more fluorescent data need collecting specifically for Dil and CTB at the olfactory bulb.
William Bui Tran
Bui Tran, William, "The Role of Olfactory-Nigral Circuitry in Neurodegeneration and Hyposmia in Rodent Model of Parkinson's Disease" (2019). Creative Components. 146.