Semester of Graduation
First Major Professor
Master of Science (MS)
The gut-brain axis is becoming a hot topic in the research world for its possible role in many disorders and diseases. As we take a deeper dive in to its role in neurodegenerative disorders like Parkinson’s disease, we present evidence of a strategy of using genetically engineered probiotic to help regulate and maintain levels of L-DOPA, the gold standard of treatment used in Parkinson’s disease patients. Evidence from trials with mice and dogs present significant findings that prove that a small change like adding a modified E. Coli probiotic may be all the change needed to provide a better, more stable treatment to neurological disorders like Parkinson’s disease.
Halley, Charlotte, "The Gut-Brain Axis: Assessment of EcNL-DOPA in mice and dogs" (2020). Creative Components. 505.