Degree Type

Creative Component

Semester of Graduation

Spring 2020


Biomedical Sciences

First Major Professor

Jonathon Mochel


Master of Science (MS)


Biomedical Sciences


The gut-brain axis is becoming a hot topic in the research world for its possible role in many disorders and diseases. As we take a deeper dive in to its role in neurodegenerative disorders like Parkinson’s disease, we present evidence of a strategy of using genetically engineered probiotic to help regulate and maintain levels of L-DOPA, the gold standard of treatment used in Parkinson’s disease patients. Evidence from trials with mice and dogs present significant findings that prove that a small change like adding a modified E. Coli probiotic may be all the change needed to provide a better, more stable treatment to neurological disorders like Parkinson’s disease.

Copyright Owner

Halley, Charlotte

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