As herbicide resistance increases in the tri-state area of Michigan, Ohio and Indiana, soybeans with tolerance to multiples herbicide modes of action are increasing in popularity. This project looks at soybeans with tolerance to glyphosate, glufosinate and dicamba to determine best practices for utilizing this technology. Eleven different herbicide treatments with variations across pre, post and late post applications, as well as an untreated control, were evaluated at three different timings across three sites to showcase differences between weed control efficacies. Soybeans were taken to harvest to showcase differences not only in weed control at this time but also in yield. Pre products applied showed varying differences of weed control across species. Post applications that contained dicamba provided better weed control of both lambsquarters and velvetleaf. A two pass approach will remain the most effective approach where multiple modes of action are used in both the pre and post timing. This provided the highest levels of yield as well as weed control at the time of harvest. This weed control approach will also decrease the selection pressure placed on the emerged weeds at the time of the post application.