Degree Type

Creative Component

Semester of Graduation

Spring 2021

Department

Biomedical Sciences

First Major Professor

Dr. Michael Kimber

Degree(s)

Master of Science (MS)

Major(s)

Biomedical Sciences

Abstract

Acute kidney injury is defined as a sudden reduction in GFR and is commonly diagnosed in critically ill patients. A lack of consensus regarding diagnostic criteria has made studying acute kidney injury a difficult task, and no standard of care currently exists in the literature. Historically, loop diuretics have been used as a primary mode of treatment in an attempt to restore normal renal function; however, limited studies have shown that treatment with loop diuretics does not improve renal function and may even increase the risk of in-hospital mortality. The goal of this paper is to review essential renal physiology, to explore the reasoning behind loop diuretic use for treatment of AKI, and to investigate mechanisms that contribute to negative outcomes following loop diuretic use.

Copyright Owner

Jacobsen, Steven

File Format

Word

Embargo Period (admin only)

4-20-2021

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