Degree Type

Creative Component

Semester of Graduation

Spring 2021

Department

Biomedical Sciences

First Major Professor

Dr. Heather Greenlee

Degree(s)

Master of Science (MS)

Major(s)

Biomedical Sciences

Abstract

Parkinson’s disease (PD) is a debilitating neurological degenerative disorder affecting millions worldwide. Pathologically, it is characterized by the death of the majority of the dopaminergic neurons in the substantia nigra region of the midbrain, leading disruption of the nigrostriatal pathway. This disruption causes characteristic motor dysfunction and tremors. The cause of PD is not well understood, although chronic neuroinflammation leading to neuron death is known to play a large role in the pathogenesis of PD. Glial cells, which are important for maintaining homeostasis in nervous tissues, maintain a steady flow of intracellular communication via signaling pathways. Gaining a better understanding of the neuro-glial crosstalk and the molecules and pathways used for this communication may lead to a better understanding of PD pathogenesis, reveal biomarkers for diagnosis, and give potential targets for new treatments. This review discusses the current knowledge of neuron-glial crosstalk and potential avenues of further research.

Copyright Owner

Reinsvold, Josef

File Format

PDF

Embargo Period (admin only)

4-22-2021

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