Degree Type

Creative Component

Semester of Graduation

Spring 2021

Department

Biomedical Sciences

First Major Professor

Dr. Joshua Beck

Degree(s)

Master of Science (MS)

Major(s)

Biomedical Sciences

Abstract

Malaria is a problem that has affected humanity for millenia. As a result, two important antimalarial drugs, chloroquine and artemisinin, have been developed to combat Malaria. However, problems with antimalarial resistance have emerged. The following review discusses the history of Malaria and the synthesis of chloroquine and artemisinin. It discusses both drugs’ mechanisms of action and Plasmodium modes of resistance. It also further discusses the widespread predicament of antimalarial drug resistance, which is being combated by artemisinin-based combination therapy. Lastly, a case study is discussed concerning the reintroduction of chloroquine in areas where it has previously failed due to resistance.

Copyright Owner

San Pedro, Ekaterina Ellyce

File Format

PDF

Embargo Period (admin only)

4-16-2021

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