Isolates of Cercospora sojina showing reduced sensitivity to quinone outside inhibitor (QoI, strobilurin) fungicides were recently recovered from soybean in Iowa. This pathogen causes frogeye leaf spot, an important foliar soybean disease that can be managed with fungicides. With the confirmation of fungicide-resistant isolates, it becomes especially important to understand when to spray and what products to use for long-term control of this disease.