Campus Units

Electrical and Computer Engineering, Materials Science and Engineering, Ames Laboratory

Document Type

Article

Publication Version

Published Version

Publication Date

2017

Journal or Book Title

AIP Advances

Volume

7

Issue

5

First Page

056711

DOI

10.1063/1.4974981

Abstract

Transcranial Magnetic Stimulation is a non-invasive clinical therapy used to treat depression and migraine, and shows further promise as treatment for Parkinson’s disease, Alzheimer’s disease, and other neurological disorders. However, it is yet unclear as to how anatomical differences may affect stimulation from this treatment. We use finite element analysis to model and analyze the results of Transcranial Magnetic Stimulation in various head models.A number of heterogeneous head models have been developed using MRI data of real patients, including healthy individuals as well as patients of Parkinson’s disease. Simulations of Transcranial Magnetic Stimulation performed on 22 anatomically different models highlight the differences in induced stimulation. A standard Figure of 8 coil is used with frequency 2.5 kHz, placed 5 mm above the head. We compare cortical stimulation, volume of brain tissue stimulated, specificity, and maximum E-field induced in the brain for models ranging from ages 20 to 60. Results show that stimulation varies drastically between patients of the same age and health status depending upon brain-scalp distance, which is not necessarily a linear progression with age.

Comments

This article is published as Syeda, Farheen, Hamzah Magsood, E. G. Lee, A. A. El-Gendy, D. C. Jiles, and R. L. Hadimani. "Effect of anatomical variability in brain on transcranial magnetic stimulation treatment." AIP Advances 7, no. 5 (2017): 056711. DOI: 10.1063/1.4974981. Posted with permission.

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Copyright Owner

The Authors

Language

en

File Format

application/pdf

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