Campus Units
Electrical and Computer Engineering, Materials Science and Engineering, Ames Laboratory
Document Type
Article
Publication Version
Published Version
Publication Date
2017
Journal or Book Title
AIP Advances
Volume
7
Issue
5
First Page
056711
DOI
10.1063/1.4974981
Abstract
Transcranial Magnetic Stimulation is a non-invasive clinical therapy used to treat depression and migraine, and shows further promise as treatment for Parkinson’s disease, Alzheimer’s disease, and other neurological disorders. However, it is yet unclear as to how anatomical differences may affect stimulation from this treatment. We use finite element analysis to model and analyze the results of Transcranial Magnetic Stimulation in various head models.A number of heterogeneous head models have been developed using MRI data of real patients, including healthy individuals as well as patients of Parkinson’s disease. Simulations of Transcranial Magnetic Stimulation performed on 22 anatomically different models highlight the differences in induced stimulation. A standard Figure of 8 coil is used with frequency 2.5 kHz, placed 5 mm above the head. We compare cortical stimulation, volume of brain tissue stimulated, specificity, and maximum E-field induced in the brain for models ranging from ages 20 to 60. Results show that stimulation varies drastically between patients of the same age and health status depending upon brain-scalp distance, which is not necessarily a linear progression with age.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright Owner
The Authors
Copyright Date
2017
Language
en
File Format
application/pdf
Recommended Citation
Syeda, F.; Magsood, H.; Lee, E. G.; El-Gendy, A. A.; Jiles, David C.; and Hadimani, R. L., "Effect of anatomical variability in brain on transcranial magnetic stimulation treatment" (2017). Electrical and Computer Engineering Publications. 138.
https://lib.dr.iastate.edu/ece_pubs/138
Included in
Biomedical Commons, Electronic Devices and Semiconductor Manufacturing Commons, Psychiatric and Mental Health Commons
Comments
This article is published as Syeda, Farheen, Hamzah Magsood, E. G. Lee, A. A. El-Gendy, D. C. Jiles, and R. L. Hadimani. "Effect of anatomical variability in brain on transcranial magnetic stimulation treatment." AIP Advances 7, no. 5 (2017): 056711. DOI: 10.1063/1.4974981. Posted with permission.