Lyric Bartholomay, Iowa State UniversityFollow
Robert M. Waterhouse, Imperial College School of Medicine
George F. Mayhew, University of Wisconsin–Madison
Corey L. Campbell, Colorado State University - Fort Collins
Kristin Michel, Kansas State University
Zhen Zou, University of California - Riverside
Jose L. Ramirez, Johns Hopkins University
Suchismita Das, Johns Hopkins University
Kanwal Alvarez, University of California - Riverside
Peter Arensburger, University of California - Riverside
Bart Bryant, Kansas State University
Sinead B. Chapman, The Broad Institute
Yuemei Dong, Johns Hopkins University
Erickson Sara M., University of Wisconsin - Madison
S.H.P. Parakrama Karunaratne, Liverpool School of Tropical Medicine
Vladimir Kokoza, University of California - Riverside
Chinnappa D. Kodira, 454 Life Sciences
Patricia Pignatelli, Liverpool School of Tropical Medicine
Sang Woon Shin, University of California - Riverside
Dana L. Vanlandingham, University of Texas Medical Branch
Peter W. Atkinson, University of California - Riverside
Bruce Birren, The Broad Institute
Geoge K. Christophides, Imperial College London
Rollie J. Clem, Kansas State University
Janet Hemingway, Liverpool School of Tropical Medicine
Stephen Higgs, University of Texas Medical Branch
Karine Megy, European Bioinformatics Institute
Hilary Ranson, Liverpool School of Tropical Medicine
Evgeny M. Zdobnov, University of Geneva
Alexander S. Raikhel, University of California, Riverside
Bruce M. Christensen, University of Wisconsin–Madison
George Dimopoulos, Johns Hopkins University
Marc A.T. Muskavitch, The Broad Institute

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The mosquito Culex quinquefasciatus poses a significant threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.


This is an author's manuscript of an article from Science 330 (2010): 88, doi:10.1126/science.1193162. Posted with permission.

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Lyric Bartholomay, et al



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