Robert M. Waterhouse, Imperial College London
Evgenia V. Kriventseva, University of Geneva
Stephen Meister, Imperial College London
Zhiyong Xi, Johns Hopkins University
Kanwal S. Alvarez, University of California, Riverside
Lyric C. Bartholomay, Iowa State UniversityFollow
Carolina Barillas-Mury, National Institutes of Health
Guowu Bian, University of California, Riverside
Stephanie Blandin, Institut de Biologie Moléculaire et Cellulaire
Bruce M. Christensen, University of Wisconsin–Madison
Yuemei Dong, Johns Hopkins University
Haobo Jiang, Oklahoma State University
Michael R. Kanost, Kansas State University
Anastasios C. Koutsos, Imperial College London
Elena A. Levashima, Institut de Biologie Moléculaire et Cellulaire
Jianyong Li, Virginia Polytechnic Institute and State University
Petros Ligoxygakis, University of Oxford
Robert M. MacCallum, Imperial College London
George F. Mayhew, University of Wisconsin–Madison
Antonio Mendes, Imperial College London
Kristin Michel, Imperial College London
Mike A. Osta, Imperial College London
Susan Paskewitz, University of Wisconsin–Madison
Sang Woon Shin, University of California, Riverside
Dina Vlachou, Imperial College London
Lihui Wang, University of Oxford
Weiqi Wei, Yale University
Liangbiao Zheng, Yale University
Zhen Zou, Oklahoma State University
David W. Severson, University of Notre Dame
Alexander S. Raikhel, University of California, Riverside
Fotis C. Kafatos, Imperial College London
George Dimopoulos, Johns Hopkins University
Evgeny M. Zdobnov, University of Geneva
Geoge K. Christophides, Imperial College London

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Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.


This article is from Science 316 (2007): 1738–1743, doi:10.1126/science.1139862.


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