G-Protein-Coupled Receptors (GPCRs) as Biopesticide Targets: A Focus on Octopamine and Tyramine Receptors
Date
Authors
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Authors
Research Projects
Organizational Units
Journal Issue
Is Version Of
Versions
Series
Department
Abstract
Plants have evolved beneficial and protective mechanisms including the production of essential oils. Essential oils are the odiferous component of plant extracts, which give plants a variety of unique properties. Essential oils are composed of various terpenoid compounds, particularly monoterpenoids and related aromatic compounds, along with sesquiterpenoids. A variety of terpenoids have been shown to have a toxic effect against insects. It is thought that this toxic action occurs through a neurological mechanism of action. Octopamine receptors and tyramine receptors are G-Protein-Coupled Receptors (GPCRs) primarily found in invertebrates, including insects. GPCRs have been a popular target for pharmaceutical development but not for agrochemical development. A summary of insect octopaminergic and tyraminergic systems is discussed.
Comments
Reprinted with permission from Biopesticides: State of the Art and Future Opportunities, ACS Symposium Series, Vol. 1172. Copyright 2014 American Chemical Society.