Campus Units

Entomology

Document Type

Article

Publication Version

Published Version

Publication Date

2016

Journal or Book Title

Trends in Parasitology

Volume

32

Issue

12

First Page

979

Last Page

990

DOI

10.1016/j.pt.2016.08.012

Abstract

Although the ability of mosquitoes to limit Plasmodium infection is well documented, many questions remain as to how malaria parasites are recognized and killed by the mosquito host. Recent evidence suggests that anti-Plasmodium immunity is multimodal, with different immune mechanisms regulating ookinete and oocyst survival. However, most experiments determine the number of mature oocysts, without considering that different immune mechanisms may target different developmental stages of the parasite. Complement-like proteins have emerged as important determinants of early immunity targeting the ookinete stage, yet the mechanisms by which the mosquito late-phase immune response limits oocyst survival are less understood. Here, we describe the known components of the mosquito immune system that limit oocyst development, and provide insight into their possible mechanisms of action.

Comments

Published as Smith, Ryan C., and Carolina Barillas-Mury. "Plasmodium Oocysts: Overlooked Targets of Mosquito Immunity." Trends in parasitology 32, no. 12 (2016): 979-990. doi: 10.1016/j.pt.2016.08.012.

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.

Language

en

File Format

application/pdf

Included in

Entomology Commons

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