Date of Award
Master of Science
Biochemistry, Biophysics and Molecular Biology
Amy H. Andreotti
T cell signaling pathway involves complicated intermolecular and intramolecular interactions. Interleukin-2 tyrosine kinase (Itk), cyclophilin A (CypA) and hematopoietic lineage cell-specific protein (HS1) are three key mediators in this pathway. This thesis explores the negative regulation of Itk activity by CypA and the autoinhibitory regulation mechanism by the HS1 protein through biochemical and structural methods.
Xu, Ruo, "T cell signaling: biochemical and structural characterization of Itk, CypA and HS1." (2009). Graduate Theses and Dissertations. 10069.