Degree Type

Thesis

Date of Award

2009

Degree Name

Master of Science

Department

Biochemistry, Biophysics and Molecular Biology

First Advisor

Amy H. Andreotti

Abstract

T cell signaling pathway involves complicated intermolecular and intramolecular interactions. Interleukin-2 tyrosine kinase (Itk), cyclophilin A (CypA) and hematopoietic lineage cell-specific protein (HS1) are three key mediators in this pathway. This thesis explores the negative regulation of Itk activity by CypA and the autoinhibitory regulation mechanism by the HS1 protein through biochemical and structural methods.

Copyright Owner

Ruo Xu

Language

en

Date Available

2012-04-06

File Format

application/pdf

File Size

93 pages

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