Degree Type
Dissertation
Date of Award
2010
Degree Name
Doctor of Philosophy
Department
Chemical and Biological Engineering
First Advisor
Rodney O. Fox
Abstract
A model study has been conducted for Flash Nanoprecipitation(FNP)) - a novel approach to produce functional nanoparticles. A mixing study has been conducted in a custom-designed microscale multi-inlet vortex reactor (MIVR) and a scalar mixing model was validated against experimental data. A microPIV experiment was conducted to further validate the turbulent model. A population balance equation (PBE) has been proposed to model the FNP process. It was furthermore, integrated into a computational fluid dynamics (CFD) simulation of to yield conditions comparable to the real experimental settings. In coping with the complicated aggregation model in the CFD code, a new numerical approach, conditional quadrature method of moments (CQMOM), has been proposed, which is capable of solving the multivariate system efficiently and accurately. It is shown that the FNP process is highly influenced by mixing effects in the microreactor and thus coupling CFD with the kinetics model is essential in obtaining valid comparisons with experiments.
DOI
https://doi.org/10.31274/etd-180810-1286
Copyright Owner
Janine Chungyin Cheng
Copyright Date
2010
Language
en
Date Available
2012-04-30
File Format
application/pdf
File Size
192 pages
Recommended Citation
Cheng, Janine Chungyin, "A comrehensive model study for Flash Nanoprecipitation: computational fluid dynamics, micro- particle image velocimetry, and population balance modeling" (2010). Graduate Theses and Dissertations. 11217.
https://lib.dr.iastate.edu/etd/11217
