Degree Type

Dissertation

Date of Award

2010

Degree Name

Doctor of Philosophy

Department

Veterinary Microbiology and Preventive Medicine

First Advisor

Ronald W. Griffith

Second Advisor

Bruce H. Janke

Abstract

The number of antimicrobials available to treat bacterial respiratory disease in goats is extremely limited. Currently, only ceftiofur has been approved for use in this species. Concerns over the development of antimicrobial resistance in bacteria that infect humans have led to proposed restrictions on the use of this drug in food-producing animals. Tulathromycin, a triamilide macrolide antibiotic found to be safe and effective against respiratory bacterial pathogens in cattle and swine, was formulated to enhance persistence in lung tissue. The Minor Use Animal Drug Program (National Research Support Project-7) identifies and supports research directed at meeting the Food and Drug Administration (FDA) requirements for drug approval in minor species or for minor uses in major species. The current work was undertaken to support FDA approval of tulathromycin in the caprine species by providing an assessment of target animal drug safety, drug tissue elimination, and drug efficacy. Tulathromycin had no detrimental clinical effects, even in animals treated with 5X the proposed label dose for three times the proposed label duration. Tissue elimination and pharmacokinetic behavior paralleled that found in both cattle and swine. Efficacy analysis was conducted on the clinical effect and pharmacokinetic behavior of tulathromycin in goats as well as in vitro antimicrobial effects on bacterial isolates recovered from goats. Bacteria isolated from goats with clinical cases of pneumonia were highly susceptible to this drug in several in vitro assays. Overall, this research demonstrated that tulathromycin would be a safe, effective, and valuable medication in the treatment of bacterial pneumonia in goats.

DOI

https://doi.org/10.31274/etd-180810-2461

Copyright Owner

Kristin A. Clothier

Language

en

Date Available

2012-04-30

File Format

application/pdf

File Size

133 pages

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