Application of fluorescence spectroscopy: excited-state dynamics, food-safety, and disease diagnosis
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The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).
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The Department of Chemistry was founded in 1880.
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1880-present
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- College of Liberal Arts and Sciences (parent college)
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Abstract
Fluorescence spectroscopy has been widely used in the study of the structure and dynamics of molecules in complex systems. Steady-state and time-resolved fluorescence methods are commonly used to gain insight into the chemical surroundings of the fluorophore. This thesis discusses a range of complex systems and phenomena that may fruitfully be examined by means of fluorescence spectroscopy, in particular: steady-state fluorescence, fluorescence quenching, fluorescence lifetime, time-resolved fluorescence anisotropy, fluorescence resonance energy transfer (FRET), and excited-state solvation dynamics. This thesis focuses on the interactions of fluorophores with biologically and environmentally important macromolecules, hydrogen atom transfer in the excited-state of medicinal pigment, and use of fluorescence from tissues for food-safety and disease diagnosis.