Degree Type

Dissertation

Date of Award

2009

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

George A. Kraus

Abstract

The synthesis of biologically active natural products has been used for the discovery of new drugs. Organic synthesis is designed for a target molecule like a novel compound by selecting optimal reactions from optimal starting materials. Each reaction and each step of a synthesis should give a good yield for the product with little work.

In this thesis, we explored both total synthesis and methodology of several natural products and analogs, especially heteroaromatic natural compounds. Chapter 1 describes an efficient synthesis of 2-substituted and 2,3-disubstituted indoles via a two-step approach in one pot involving a six-electron ring closure. Chapter 2 describes the direct synthesis of neocryptolepine in four steps in two pots. Chapter 3 is about synthesis studies towards the unique κ opioid receptor agonist salvinorin A. Chapter 4 describes a direct approach to the synthesis of methyllycaconitine, one of the diterpenoid alkaloids.

Copyright Owner

Haitao Guo

Language

en

Date Available

2012-04-30

File Format

application/pdf

File Size

126 pages

Included in

Chemistry Commons

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