Date of Award
Doctor of Philosophy
Genetics, Development and Cell Biology
Bioinformatics and Computational Biology
Peter J. Reilly
The benefits of modeling are well recognized throughout engineering. Most systems constructed by people today are simply too complex to fully understand in all situations. The disciplines of systems biology, genetic engineering, and synthetic biology have been influenced by the engineering approach, and as such, as they mature these fields will also benefit from modeling. However, biological systems may prove to be more complicated and so there is an urgent need for advancement of methods for modeling biological systems.
This dissertation chronicles one group's attempt to apply modeling methods to improve their understanding of genotype to phenotype mapping as well as to identify new constructs for synthetic biology. When we began, there was little existing work to leverage, so we started at foundational levels: characterizing a formalism, developing a modeling environment and optimization methods, and applying these methods to several independent problems.
Kent Allan Vander Velden
Vander Velden, Kent Allan, "Modeling, simulation, synthesis, and optimization of biochemical networks" (2009). Graduate Theses and Dissertations. 12243.