Date of Award
Master of Science
Rick L Sharp
When exposed to resistance exercise, untrained muscle can develop micro-tears and disruptions in the sarcomeres. This is followed by swelling, pain and decreased muscle performance, which can be attenuated by taking β-hydroxy-β-methylbutyrate (HMB). The acute phase response is the inflammatory change that occurs to repair damaged tissue, and is mediated by cytokines. It is the purpose of this study to determine if HMB can influence the acute phase response. 32 untrained subjects (16 men, 16 women) completed three sets of 50 eccentric leg extensions on each leg. The subjects were group matched and randomly assigned to one of three treatment groups: placebo (CON), HMB pre exercise (PRE) or HMB pre-exercise and for 4 days following the exercise protocol (PRE-POST). We observed a drop in serum concentration of IL-1ra and TNF-α for the CON, that was attenuated by HMB at 48h and 72h post exercise (p<.05). The observed reduction in acute phase response suggests that HMB may moderate inflammatory response to exercise induced muscle damage.
Paul Raymond Vulcan
Vulcan, Paul Raymond, "Role of β-Hydroxy-β-methylbutyrate (HMB) on inflammation after eccentric exercise" (2012). Graduate Theses and Dissertations. 12501.