Date of Award
Master of Science
Food Science and Human Nutrition
The purpose of this project was to observe whether consuming a DHA supplement with or without a meal influenced the bioavailability of the DHA supplement. Healthy males (n = 109) aged 18-45 years were randomized to 4 study groups that included 200 mg/d DHA consumed with a meal, 200 mg/d DHA consumed fasted, 1000 mg/d DHA consumed with a meal or 1000 mg/d DHA consumed in a fasted state over 8 weeks. Fasted venous blood samples were collected pre- and post-DHA supplementation for analysis of plasma phospholipid (PL) fatty acid analysis. Plasma PL DHA increased significantly in all groups (P < 0.0001). The increase in DHA was significantly different between all dose groups (200 mg versus 1000 mg; P < 0.0001). There were no differences between the meal or fasted groups. Thus, consuming a DHA supplement with a meal did not increase the bioavailability of the DHA supplement.
Stephanie J Kratzer
Kratzer, Stephanie J., "Influence of food on the bioavailability of a docosahexaenoic acid supplement" (2012). Graduate Theses and Dissertations. 12869.