Degree Type

Dissertation

Date of Award

2013

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

George A. Kraus

Abstract

The synthesis of biologically active molecules represents an important aspect of organic chemistry. Renewables, and their respective green syntheses, embody another essential aspect of organic chemistry receiving growing interest. Chapter 1 describes extensions of the Kraus indole synthesis toward 2-substituted and 2,3-disubstituted indoles, as well as biologically attractive indolo[2,1-a]isoquinolines. Chapter 2 describes our recent synthetic work directed toward commodity maleic acid and the first reported furan-based ionic liquids from renewable feedstocks. Chapter 3 describes our total synthesis of an mRNA aptamer ligand, PDC-Gly, and its dye coupled forms, plus aminoglycoside dye coupled ligands used in molecular imaging.

DOI

https://doi.org/10.31274/etd-180810-3258

Copyright Owner

Jonathan Scott Beasley

Language

en

File Format

application/pdf

File Size

75 pages

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