Date of Award
Doctor of Philosophy
George A. Kraus
The synthesis of biologically active molecules represents an important aspect of organic chemistry. Renewables, and their respective green syntheses, embody another essential aspect of organic chemistry receiving growing interest. Chapter 1 describes extensions of the Kraus indole synthesis toward 2-substituted and 2,3-disubstituted indoles, as well as biologically attractive indolo[2,1-a]isoquinolines. Chapter 2 describes our recent synthetic work directed toward commodity maleic acid and the first reported furan-based ionic liquids from renewable feedstocks. Chapter 3 describes our total synthesis of an mRNA aptamer ligand, PDC-Gly, and its dye coupled forms, plus aminoglycoside dye coupled ligands used in molecular imaging.
Jonathan Scott Beasley
Beasley, Jonathan Scott, "Synthesis of heterocycles: Indolo[2,1-a]isoquinolines, renewables, and aptamer ligands for cellular imaging" (2013). Graduate Theses and Dissertations. 13236.