Degree Type
Dissertation
Date of Award
2013
Degree Name
Doctor of Philosophy
Department
Chemistry
First Advisor
George A. Kraus
Abstract
The synthesis of biologically active molecules represents an important aspect of organic chemistry. Renewables, and their respective green syntheses, embody another essential aspect of organic chemistry receiving growing interest. Chapter 1 describes extensions of the Kraus indole synthesis toward 2-substituted and 2,3-disubstituted indoles, as well as biologically attractive indolo[2,1-a]isoquinolines. Chapter 2 describes our recent synthetic work directed toward commodity maleic acid and the first reported furan-based ionic liquids from renewable feedstocks. Chapter 3 describes our total synthesis of an mRNA aptamer ligand, PDC-Gly, and its dye coupled forms, plus aminoglycoside dye coupled ligands used in molecular imaging.
DOI
https://doi.org/10.31274/etd-180810-3258
Copyright Owner
Jonathan Scott Beasley
Copyright Date
2013
Language
en
File Format
application/pdf
File Size
75 pages
Recommended Citation
Beasley, Jonathan Scott, "Synthesis of heterocycles: Indolo[2,1-a]isoquinolines, renewables, and aptamer ligands for cellular imaging" (2013). Graduate Theses and Dissertations. 13236.
https://lib.dr.iastate.edu/etd/13236
