Degree Type

Thesis

Date of Award

2013

Degree Name

Master of Science

Department

Chemistry

First Advisor

Arthur H. Winter

Abstract

A chemical amplifier is a structure that translates a single bond-breaking event into release of numerous chemical outputs. In this way, a single bond cleavage input reaction (e.g. a reaction triggered by an analyte, a photon, or an enzyme) can be translated into the release of numerous output chemical cargoes. Outputs can take the form of reporting molecules (e.g. fluorescent dyes), biomolecules, or drugs. This kind of chemical amplifier has numerous applications in chemical sensing, molecular machines, and in drug delivery. Herein we report a detailed study of self-immolative linkers and the synthesis of a chemical amplifier based on a mellitic acid derived methyl ester using a novel synthetic method. Similar molecules, requiring multi-step synthesis, are also discussed.

DOI

https://doi.org/10.31274/etd-180810-3546

Copyright Owner

Mark James Juetten

Language

en

File Format

application/pdf

File Size

48 pages

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