Date of Award
Doctor of Philosophy
Christine A. Petersen
Leishmania amazonensis is an intracellular protozoan parasite responsible for
chronic cutaneous leishmaniasis (CL). CL is a neglected tropical disease responsible
for infecting millions of people worldwide. L. amazonensis promotes alteration of
various signaling pathways that are essential for host cell survival. Specifically, through
parasite-mediated phosphorylation of extracellular signal regulated kinase (ERK), L.
amazonensis inhibits cell-mediated parasite killing and promotes its own survival by coopting
multiple host cell functions. In this review we highlight Leishmania-host cell
signaling alterations focusing on those specific to 1) motor proteins, 2) prevention of
NADPH subunit phosphorylation impairing reactive oxygen species production (ROS),
and 3) localized endosomal signaling to up-regulate ERK phosphorylation. This review
will focus upon mechanisms and possible explanations as to how Leishmania spp.
evades the various layers of defense employed by the host immune response by looking at scaffolding complexes, reactive oxygen species, and motor proteins.
Martinez, Pedro, "Chronic infection by Leishmania amazonensis mediated through MAPK ERK mechanisms" (2014). Graduate Theses and Dissertations. 13857.