Degree Type
Thesis
Date of Award
2014
Degree Name
Master of Science
Department
Materials Science and Engineering
First Advisor
Rebecca Cademartiri
Second Advisor
Kaitlin Bratlie
Abstract
One of the most urgent problems in the fields of medicine and agriculture is the decreasing effectiveness of antibiotics. Once a miracle drug, antibiotics have recently become associated with the creation of antibiotic-resistant bacteria. The main limitations of these
treatments include lack of both adaptability and specificity. To overcome these shortcomings of current antibiotic treatments, there has been a renewed interest in bacteriophage research.
Bacteriophages are naturally-occurring viruses that lyse bacteria. They are highly specific, with each bacteriophage type lysing a narrow range of bacteria strains. Bacteriophages are also ubiquitous biological entities, populating environments where bacterial growth is supported. Just as humans are exposed to bacteria in their daily lives, we are exposed to bacteriophages as well.
To use bacteriophages in practical applications, they must be delivered to the site of an infection in a controlled-release system. Two systems were studied to observe their support of bacteriophage lytic activity, as well as investigate the possibility of controlling bacteriophage release rates. First, hydrogels were studied, using crosslinking and blending techniques to achieve a range of release profiles. Second, polyanhydride microparticles were studied, evaluating release rates as a function of monomer chemistries.
DOI
https://doi.org/10.31274/etd-180810-2525
Copyright Owner
Alyssa Marie Brown
Copyright Date
2014
Language
en
File Format
application/pdf
File Size
78 pages
Recommended Citation
Brown, Alyssa Marie, "Polymer-based delivery systems for support and delivery of bacteriophages" (2014). Graduate Theses and Dissertations. 13859.
https://lib.dr.iastate.edu/etd/13859
