Molecularly imprinted nanoparticles (MINPs) as antibody mimics

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2015-01-01
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Awino, Joseph
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Yan Zhao
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Altmetrics
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Chemistry
Abstract

This dissertation presents a simple but effective method for the design and synthesis of molecularly imprinted nanoparticles (MINPs) as antibody mimics. The MINPs resembled proteins in their water-solubility, discrete nanosized structure, and in their ability to contain hydrophobic binding pockets in the interior while maintaining a hydrophilic exterior by virtue of the sugar-derived ligands incorporated onto the surface during the post-functionalization. A variety of MINPs with guest-tailored and modifiable hydrophobic binding pockets were synthesized and their applications in biomimetic recognition, molecular sensing, and generation of plastic monoclonal antibodies investigated.

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Thu Jan 01 00:00:00 UTC 2015