Degree Type
Dissertation
Date of Award
2015
Degree Name
Doctor of Philosophy
Department
Chemistry
First Advisor
Yan Zhao
Abstract
This dissertation presents a simple but effective method for the design and synthesis of molecularly imprinted nanoparticles (MINPs) as antibody mimics. The MINPs resembled proteins in their water-solubility, discrete nanosized structure, and in their ability to contain hydrophobic binding pockets in the interior while maintaining a hydrophilic exterior by virtue of the sugar-derived ligands incorporated onto the surface during the post-functionalization. A variety of MINPs with guest-tailored and modifiable hydrophobic binding pockets were synthesized and their applications in biomimetic recognition, molecular sensing, and generation of plastic monoclonal antibodies investigated.
DOI
https://doi.org/10.31274/etd-180810-3897
Copyright Owner
Joseph Khadori Awino
Copyright Date
2015
Language
en
File Format
application/pdf
File Size
179 pages
Recommended Citation
Awino, Joseph Khadori, "Molecularly imprinted nanoparticles (MINPs) as antibody mimics" (2015). Graduate Theses and Dissertations. 14346.
https://lib.dr.iastate.edu/etd/14346
