Degree Type

Dissertation

Date of Award

2015

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

Yan Zhao

Abstract

This dissertation presents a simple but effective method for the design and synthesis of molecularly imprinted nanoparticles (MINPs) as antibody mimics. The MINPs resembled proteins in their water-solubility, discrete nanosized structure, and in their ability to contain hydrophobic binding pockets in the interior while maintaining a hydrophilic exterior by virtue of the sugar-derived ligands incorporated onto the surface during the post-functionalization. A variety of MINPs with guest-tailored and modifiable hydrophobic binding pockets were synthesized and their applications in biomimetic recognition, molecular sensing, and generation of plastic monoclonal antibodies investigated.

DOI

https://doi.org/10.31274/etd-180810-3897

Copyright Owner

Joseph Khadori Awino

Language

en

File Format

application/pdf

File Size

179 pages

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