Degree Type

Dissertation

Date of Award

2015

Degree Name

Doctor of Philosophy

Department

Chemistry

First Advisor

Yan Zhao

Abstract

This dissertation presents a simple but effective method for the design and synthesis of molecularly imprinted nanoparticles (MINPs) as antibody mimics. The MINPs resembled proteins in their water-solubility, discrete nanosized structure, and in their ability to contain hydrophobic binding pockets in the interior while maintaining a hydrophilic exterior by virtue of the sugar-derived ligands incorporated onto the surface during the post-functionalization. A variety of MINPs with guest-tailored and modifiable hydrophobic binding pockets were synthesized and their applications in biomimetic recognition, molecular sensing, and generation of plastic monoclonal antibodies investigated.

Copyright Owner

Joseph Khadori Awino

Language

en

File Format

application/pdf

File Size

179 pages

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