Degree Type

Thesis

Date of Award

2015

Degree Name

Master of Science

Department

Chemistry

Major

Organic Chemistry

First Advisor

Levi M. Stanley

Abstract

Artificial metalloenzymes are an important class of hybrid catalysts for enantioselective, regioselective and chemoselective organic transformations. Despite several limitations associated with this type of hybrid catalysts system and their limited development relative to small molecule catalysts, significant advances have been achieved over the past few decades. This thesis describes the background, applicability of such hybrid catalysts, anchoring strategies and methods involved in the improvement of catalytic activities of artificial metalloenzymes. The generation of a thermostable human carbonic anhydrase mutant, activity determination, generation of an artificial metalloenzyme (manganese-substituted human carbonic anhydrase) and its use as a catalyst for enantioselective epoxidation of olefins is also described.

Copyright Owner

Sagarika Tharangie Weerasekara

Language

en

File Format

application/pdf

File Size

63 pages

Included in

Chemistry Commons

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