Degree Type

Thesis

Date of Award

2018

Degree Name

Master of Science

Department

Food Science and Human Nutrition

Major

Diet and Exercise

First Advisor

Rick L. Sharp

Abstract

Recently, low serum concentrations of 25-hydroxyvitamin D [25(OH)D] have been linked to disturbances in glucose metabolism, development of type 2 diabetes, and increased risk of metabolic syndrome (MetS). Moreover, deficiency of vitamin D is now recognized to be highly prevalent in the U.S. and worldwide, impacting between 30% and 50% of the general population. Therefore, the objective of this research study is to examine the associations between serum 25-hyroxyvitamin D and MetS. Data were collected from the Nutritional Interventions for Age-Related Muscular Function and Strength Losses Study. From this cohort, 186 independently living males and females over the age of 60, with vitamin D levels between 18 ng/mL and 30 ng/mL, without any existing liver or kidney disease or uncontrolled diabetes mellitus or type 1 diabetes mellitus requiring insulin, provided baseline data. A Pearson correlation coefficient of 0.02 with non-significant p-value of 0.77 was found between MetS score and 25(OH)D. Factors such as average heart rate (p <0.05), weight (p <0.001) , BMI (p <0.001), LDL:HDL ratio (p <0.01), android fat (%) (p < 0.001), gynoid fat mass (p <0.001), and gynoid fat (%) (p <0.01) were found to have significant associations with the MetS score. A backwards stepwise regression indicated that android fat (%) (p <0.001), gynoid fat (%) (p = 0.001), total cholesterol (p <0.001), VLDL cholesterol (p <0.001), and LDL:HDL ratio (p <0.001) were most predictive of the MetS score. In conclusion, the major finding of this study was that the combination of android fat (%), gynoid fat (%), total cholesterol, VLDL cholesterol, and the LDL:HDL ratio were predictive of the MetS score. However, no significant association between low vitamin D status and prevalence of MetS could be established.

DOI

https://doi.org/10.31274/etd-180810-6001

Copyright Owner

Allison Ann Hedges

Language

en

File Format

application/pdf

File Size

51 pages

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