Date of Award
Master of Science
Molecularly imprinted nanoparticles (MINPs), which have guest-complementary binding sites, are obtained by doubly cross-linking micelles containing appropriate guests. One of the most important building blocks of MINPs is the cross-linker that can profoundly affect the structure and property of MINPs. In the traditional method, 1,4-diazidobutane-2,3-diol is used as the cross-linker for the cross-linkable surfactants. In this work, a new cross-linker (Compound 11) is used instead. This new cross-linker can improve the binding affinity between MINPs and their guests, due to the more rigid structure compared to that from 1,4-diazidobutane-2,3-diol. In addition, with a hydroxylamine functional group in the structure, the cross-linker allows MINPs to be post-modified to increase the path of the binding pocket, further improve the binding affinity.
Zhang, Shize, "Effects of surface cross-linker on the binding properties of imprinted micelles" (2018). Graduate Theses and Dissertations. 16903.