Degree Type

Thesis

Date of Award

2018

Degree Name

Master of Science

Department

Chemistry

Major

Organic Chemistry

First Advisor

Yan Zhao

Abstract

Molecularly imprinted nanoparticles (MINPs), which have guest-complementary binding sites, are obtained by doubly cross-linking micelles containing appropriate guests. One of the most important building blocks of MINPs is the cross-linker that can profoundly affect the structure and property of MINPs. In the traditional method, 1,4-diazidobutane-2,3-diol is used as the cross-linker for the cross-linkable surfactants. In this work, a new cross-linker (Compound 11) is used instead. This new cross-linker can improve the binding affinity between MINPs and their guests, due to the more rigid structure compared to that from 1,4-diazidobutane-2,3-diol. In addition, with a hydroxylamine functional group in the structure, the cross-linker allows MINPs to be post-modified to increase the path of the binding pocket, further improve the binding affinity.

Copyright Owner

Shize Zhang

Language

en

File Format

application/pdf

File Size

72 pages

Included in

Chemistry Commons

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