Degree Type

Thesis

Date of Award

2018

Degree Name

Master of Science

Department

Veterinary Clinical Sciences

Major

Veterinary Clinical Science

First Advisor

Albert Jergens

Abstract

The gastrointestinal (GI) microbiota in healthy cats is altered in IBD. Little research has been performed to identify whether specific bacterial groups are associated with small cell GI lymphoma (LSA).

Fourteen cats with IBD and 14 cats with small cell GI LSA were included in this retrospective case control study. A search of the medical records was performed to identify cats diagnosed with IBD and with GI LSA. Bacterial groups identified by FISH in GI biopsies were compared between cohorts and correlated to CD11b+ and NF-kappaB expression.

Fusobacterium spp. were higher in cats with small cell GI LSA in ileal and colonic adherent mucus, and combined colonic compartments compared to cats with IBD. Bacteroides spp. were higher in ileal adherent mucus and 3 combined ileal compartments of cats with small cell GI LSA. There were significant correlations between Fusobacterium spp. totals and CD11b+ cell and NF-kappaB expression.

The bacterial alterations appreciated might be influential in development of small cell GI LSA, and should drive further studies to elucidate the effects of microbial-mediated inflammation on GI cancer progression.

Copyright Owner

Kayode Garraway

Language

en

File Format

application/pdf

File Size

45 pages

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