Degree Type

Thesis

Date of Award

2019

Degree Name

Master of Science

Department

Veterinary Microbiology and Preventive Medicine

Major

Veterinary Microbiology

First Advisor

Mark . Lyte

Abstract

Campylobacter jejuni is the leading food-borne bacterial pathogen, which causes campylobacteriosis in human. The bacterium is usually carried asymptomatically in the intestinal tract of food-producing animals such as chicken, cattle, and porcine, which contributes to its transmission in the environment. Interventions in the colonization of this bacterium in food-producing animals is one of the promising ways to control for food-borne illness in humans. However, up to date, there has not been an effective measures developed that can successfully reduce the colonization level of this bacterium in food-producing animals. Microbial endocrinology is an interdisciplinary field of research that studies the interaction between gut microbiota and host through neurotransmitters. Studies in this field have provided novel understandings on the pathogenesis of many other food-borne bacteria such as pathogenic Escherichia coli, Salmonella spp., and Vibrio spp. Compared to them, little is known of C. jejuni, and the response of this bacteria to a major intestinal neurotransmitter, dopamine (DA), has not, to our knowledge been previously examined. The results of this study demonstrated that intestinal catecholamine neurotransmitters norepinephrine (NE) and DA can significantly enhance the growth of 3 strains of C. jejuni in a strain-dependent manner. Furthermore, the study identified a key factor, pyruvate, which involves in the DA-mediated but not NE-mediated growth stimulation in C. jejuni.

Copyright Owner

Meicen Liu

Language

en

File Format

application/pdf

File Size

67 pages

Share

COinS