The present study tested a modification of the Dual Pathway Model describing the development of binge eating (Stice, 1994) with difficulties in emotion regulation as a mediator in the place of negative affect, as well as self-compassion as a moderator. A total of 440 undergraduate students attending a predominately White, Midwestern university completed an online survey. Due to significantly different mean differences on most variables, results were examined separately for women (N = 230) and men (N = 205). The moderation of self-compassion on the association between body dissatisfaction and difficulties in emotion regulation was tested using PROCESS (Hayes, 2013) and was found to be non-significant. Using path analysis, direct and indirect effects of body dissatisfaction, restricted eating, difficulties in emotion regulation, and binge eating were tested. A multiple-group analysis demonstrated gender differences for these relationships; in particular, the path from body dissatisfaction to restricted eating was significant for women but not for men. The mediation of body dissatisfaction to binge eating through restricted eating was not significant for either group. Restricted eating and difficulties in emotion regulation mediated the indirect effect of body dissatisfaction to binge eating only for women. The mediation of body dissatisfaction to binge eating through difficulties in emotion regulation was supported for women and men. Post-hoc analyses supported the moderation effect of self-compassion on the association between body dissatisfaction and negative affect for women only. Specifically, women with greater in self-compassion reported lower negative affect in the face of body dissatisfaction. Finally, post-hoc analyses examining the paths of the original Dual Pathway Model were conducted. Results showed only the mediation from body dissatisfaction to binge eating through negative affect was supported, both for women and men. Limitations, contributions, future research directions, and implications were discussed.