Degree Type

Thesis

Date of Award

2020

Degree Name

Master of Science

Department

Animal Science

Major

Genetics and Genomics

First Advisor

Jack C.M. Dekkers

Abstract

Infectious swine diseases have the potential to decimate the health and productivity of swine farms. One of the most economically concerning diseases is caused by the Porcine Reproductive and Respiratory Syndrome (PRRS) virus. While swine producers can implement vaccines, medications, or antibiotics and antiviral drugs, many infectious pathogens such as the PRRS virus have shown these strategies to be ineffective. One complimentary strategy would be to select pigs for increased disease resistance or resilience, where disease resilience is defined as an animal’s ability to maintain performance when infected. However, the elite populations that are used for genetic improvement are typically kept in high health conditions, making it difficult and impractical for swine breeders to use phenotypic selection in an environment with exposure to disease to select for increased disease resilience. Previous research has shown that host response to PRRS virus infection has a sizable genetic component and revealed a Quantitative Trait Locus (QTL) for host response to PRRS virus infection on Sus Scrofa Chromosome (SSC) 4. A putative causative mutation in the GBP5 gene was identified for this QTL. This mutation was determined to be in complete linkage disequilibrium with the single nucleotide polymorphism (SNP) WUR10000125 (WUR) that was included on commercial SNP panels. However, this was based on data from one genetic source.

DOI

https://doi.org/10.31274/etd-20200902-71

Copyright Owner

Ryan Lee Jeon

Language

en

File Format

application/pdf

File Size

131 pages

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