Degree Type

Dissertation

Date of Award

2020

Degree Name

Doctor of Philosophy

Department

Veterinary Diagnostic and Production Animal Medicine

Major

Population Sciences in Animal Health

First Advisor

Patrick J. Gorden

Abstract

The lack of pain modulation strategies in the dairy industry has both significant economic and welfare implications. This is most prevalent in lactating dairy cattle. The most painful afflictions in production animals are lameness and mastitis. To date, there remains no labeled pain control therapeutics for lactating dairy cattle. There is, therefore, a critical need to develop adequate strategies for pain modulation in the livestock industry. Meloxicam is a commonly used extra-label non-steroidal anti-inflammatory drugs (NSAIDs) in the US dairy industry. Chapter 2 describes an analgesic comparison study in amphotericin B induced lameness.

Though, the US does not allow extra-label drug use (ELDU) for production enhancement, as has been shown by several research groups, under the guidelines of the Animal Medicinal Drug Use Clarification Act (AMDUCA), meloxicam can be used to provide pain relief. Chapters 3 and 4 discuss plasma and milk pharmacokinetic properties of meloxicam administration for judicious extra-label use.

One of the major reasons for an absence of approved analgesics for lameness-associated pain in cattle is that a consistent, reproducible, clinically relevant lameness model has not been validated in the bovine species. Chapter 5 provides the validation of an embedded microcomputer-based force plates system for use in a bovine lameness model. Chapter 6 discusses descriptive statistics of lameness detection modalities in naturally occurring lameness. Lastly, chapter 7 compares induction approaches to create a consistent, reproducible, clinically relevant lameness model for future bovine analgesic efficacy studies.

DOI

https://doi.org/10.31274/etd-20200902-162

Copyright Owner

Rochelle Warner

Language

en

File Format

application/pdf

File Size

172 pages

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