This study was initiated to quantify the agronomic performance penalties resulting from use of second-generation hybrid seed corn (saved seed). While this is not common practice in the United States, it is common in many corn-producing areas around the world. The agronomics of this practice were evaluated to determine the value (if any) of planting second-generation seed corn. A yield and grain quality study was conducted at the Iowa State University Northeast Research and Demonstration Farm near Nashua, Iowa to compare F1 (commercial seed), F2 (saved seed), and a combination of F1/F2 seed with three different corn hybrids differing in relative maturity (RM).