Bovine respiratory disease is a very significant disease affecting feedlot cattle across the US. We are interested in investigating the genetic control of response to respiratory disease vaccines as a method of reducing respiratory disease in feedlots in the future. When beginning to investigate genetic control of a new trait, it is important to characterize nongenetic effects on that trait. Therefore, the objective of this study was to evaluate the impact of environmental factors on the serological response to vaccination for a commercial bovine viral diarrhea (BVDV2) vaccine.