Title
Characterizing the Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides
Document Type
Article
Publication Date
2008
Journal or Book Title
Journal of Agricultural and Food Chemistry
Volume
56
Issue
12
First Page
4359
Last Page
4366
DOI
10.1021/jf800411v
Abstract
In this paper we characterize the metabolic fingerprint and first reported anti-inflammatory activity of Hypericum gentianoides. H. gentianoides has a history of medical use by Native Americans, but it has been studied very little for biological activity. High-performance liquid chromatography (HPLC) and liquid chromatography−electrospray ionization−mass spectrometry (LC-ESI-MS) analyses of a methanol extract show that H. gentianoides contains a family of over nine related compounds that have retention times, mass spectra, and a distinctive UV absorption spectra characteristic of certain acyl-phloroglucinols. These metabolites are abundant relative to other secondary products present in H. gentianoides, accounting for approximately 0.2 g per gram of dry plant tissue. H. gentianoides methanol extracts and a specific semipreparative HPLC fraction from these extracts containing the putative acyl-phloroglucinols reduce prostaglandin E2 synthesis in mammalian macrophages.
Copyright Owner
American Chemical Society
Copyright Date
2008
Language
en
File Format
application/pdf
Recommended Citation
Hillwig, Matthew L.; Hammer, Kimberly D.P.; Birt, Diane F.; and Wurtele, Eve S., "Characterizing the Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides" (2008). Food Science and Human Nutrition Publications. 19.
https://lib.dr.iastate.edu/fshn_ag_pubs/19
Included in
Chemical and Pharmacologic Phenomena Commons, Food Science Commons, Genetics Commons, Human and Clinical Nutrition Commons, Medical Pharmacology Commons, Pharmacology Commons
Comments
Posted with permission from Journal of Agricultural and Food Chemistry 56, no. 12 (2008): 4359–4366, doi:10.1021/jf800411v. Copyright 2008 American Chemical Society.