Title
Association of Oxidative Stress, Iron, and Centralized Fat Mass in Healthy Postmenopausal Women
Document Type
Article
Publication Date
6-2009
Journal or Book Title
Journal of Women's Health
Volume
18
Issue
6
First Page
795
Last Page
801
DOI
10.1089=jwh.2008.0988
Abstract
Objective: Centralized adiposity, insulin resistance, excess iron, and elevated oxidative stress place postmenopausal women at risk for atherosclerotic cardiovascular disease (CVD). The objective of this study was to determine the relationship among excess iron, oxidative stress, and centralized fat mass in healthy postmenopausal women. Methods: The parent project recruited healthy women for a randomized, double-blind, clinical trial designed to examine the effect of soy isoflavones on bone. At baseline ( n = 122), we measured three antioxidant enzymes, iron status indices (serum ferritin among others), oxidative stress indices (oxidized low-density lipoprotein [oxLDL], urinary isoprostanes [PGF2α], protein carbonyls, DNA damage), and waist, hip, and thigh fat mass using dual-energy x-ray absorptiometry (DXA). We calculated insulin resistance using the homeostasis model assessment (HOMA). Multiple regression analysis was used to determine the CVD risk factors that contributed to oxidative stress and centralized fat mass (waist + hip/thigh = AndGynFM ratio). Results: Almost 14% ( p < 0.0005) of the variability in oxLDL was accounted for by AndGynFM ratio (6.1%, p < 0.0005), age (4.0%, p = 0.012), and serum iron (2.8%, p = 0.053). Similarly, 16% ( p < 0.0001) of the variability in PGF2α was accounted for by the AndGynFM ratio (4.8%, p = 0.011), HOMA (3.9%, p = 0.021), and serum iron (2.7%, p = 0.054). We accounted for 33% ( p ≤ 0.0001) of the variability in AndGynFM ratio by high-density lipoprotein cholesterol (HDL-C) (4.3%, p = 0.008), ferritin (4.9%, p = 0.005), HOMA (4.5%, p = 0.006), oxLDL (2.6%, p = 0.04), and PGF2α (3.0%, p = 0.025). Conclusions: Our study suggests that reducing centralized fat mass and maintaining a favorable lipid profile, antioxidant status, and iron status all may be important in protecting postmenopausal women from atherosclerotic CVD. [ABSTRACT FROM AUTHOR]
Copyright Owner
Mary Ann Liebert, Inc.
Copyright Date
2009
Language
en
File Format
application/pdf
Recommended Citation
Crist, Betsy L.; Alekel, D. Lee; Ritland, Laura M.; Hanson, Laura N.; Genschel, Ulrike; and Reddy, Manju B., "Association of Oxidative Stress, Iron, and Centralized Fat Mass in Healthy Postmenopausal Women" (2009). Food Science and Human Nutrition Publications. 67.
https://lib.dr.iastate.edu/fshn_ag_pubs/67
Included in
Biochemistry Commons, Food Science Commons, Human and Clinical Nutrition Commons, Other Cell and Developmental Biology Commons, Other Medicine and Health Sciences Commons
Comments
This is a copy of an article published in the Journal of Women's Health © 2009 copyright Mary Ann Liebert, Inc.; Journal of Women's Health is available online at: http://online.liebertpub.com.